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Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
AKA; ATH4C; basic helix-loop-helix transcription factor; bHLHa6; cb260; chunp6899; class A basic helix-loop-helix protein 6; Helix-loop-helix protein mATH-4C; Math4C; Neurod3; NEUROG1; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; neurogenic differentiation factor 3; neurogenin; neurogenin 1; neurogenin related protein-1; neurogenin-1; Neurogenin-related protein 1; NGN; Ngn1; NGN-1; ngr1; transcription factor; Zath4c; zNgn1
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